Further Information
ZIP7 Antibody: KE4, HKE4, ZIP7, RING5, H2-KE4, D6S115E, D6S2244E, Zinc transporter SLC39A7, Histidine-rich membrane protein Ke4
WB: 0.5-1 μg/mL; IHC: 2.5 μg/mL; IF: 20 μg/mL.
Antibody validated: Western Blot in human, mouse and rat samples; Immunohistochemistry in human samples; Immunofluorescence in human samples. All other applications and species not yet tested.
ZIP7 Antibody: The zinc transporter ZIP7, also known as SLC39A7, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP7 was initially identified while characterizing genes in the major histocompatibility complex on chromosome 17. ZIP7 mRNA is abundantly and widely expressed and the protein localizes to the Golgi apparatus. It functions to transport intracellular zinc from the Golgi apparatus to the cytoplasm of the cell. ZIP7 expression is expressed by zinc. ZIP7 has been suggested to act a hub for tyrosine kinase activation and may thus be a potential therapeutic target for diseases such as cancer where prevention of tyrosine kinase activation would be advantageous.
- Dufner-Beattie et al. J. Biol. Chem.2003; 278:50142-50.
- Eide. Pflugers Arch.2004; 447:796-800.
- Taylor and Nicohlson. Biochim. Biophys. Acta.2003; 1611:16-30.
- Lai et al. Genomics1994; 23:338-42.
ZIP7 Antibody is supplied in PBS containing 0.02% sodium azide.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Anti-ZIP7 antibody (6093) was raised against a peptide corresponding to 17 amino acids near the amino terminus of human ZIP7.
The immunogen is located within amino acids 20-70 of ZIP7.
Human ZIP7 has one isoform (469aa, 50kD). Mouse ZIP7 has one isoform (476aa, 51kD) and Rat ZIP7 also has one isoform (468aa, 50kD). 6093 can detect human, mouse and rat.
7922
solute carrier family 39 (zinc transporter), member 7
SLC39A7
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 50kD
Observed: 50kD
NP_001070984
117553619
ZIP7 Antibody is affinity chromatography purified via peptide column.
Cancer,Cell Cycle
Q92504
Optimal dilutions for each application to be determined by the researcher.
Independent Antibody Validation in Cell lines (Figure 1) shows similar ZIP7 expression profile in human cell lines detected by two independent anti-ZIP7 antibodies that recognize different epitopes, 6093 against N-terminus domain and 24-029 against recombinant fusion protein. ZIP7 proteins are detected in all tested cell lines at different expression levels by the two independent antibodies.