Antibody Clonality:
Polyclonal
Applications:- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Western Blot (WB)
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![Western blot analysis of FRL1 in EL4 cell lysate with FRL1 antibody at 1 μg/mL. Western blot analysis of FRL1 in EL4 cell lysate with FRL1 antibody at 1 μg/mL.](https://www.prosci-inc.com/static-images/7101oem.gif)
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![Immunofluorescence of FRL1 in EL4 cells with FRL1 antibody at 20 μg/mL. Immunofluorescence of FRL1 in EL4 cells with FRL1 antibody at 20 μg/mL.](https://www.prosci-inc.com/static-images/FRL1-Antibody_IF_7101.jpg)
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United States.
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Further Information
FRL1 Antibody: FMNL, FHOD4, KW-13, C17orf1, C17orf1B, FMNL, Formin-like protein 1, CLL-associated antigen KW-13
FRL1 antibody can be used for detection of FRL1 by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
FRL1 Antibody: The Formin-like protein 1 (FRL1) gene encodes a formin-related protein which has been implicated in morphogenesis, cyokinesis, and cell polarity. Formins are a conserved class of proteins expressed in all eukaryotes and have one DAD (diaphanous autoregulatory domain), one FH2 (formin homology 2) domain and one GBD/FH3 (Rho GTPase-binding / formin homology 3) domain. FRL1 is located in the cytoplasm and is highly expressed in the spleen, lymph node and bone marrow cells. FRL1 possibly has a role in the control of cell motility, survival of macrophages and cytoskeletal organization.
- Katoh M and Katoh M. Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico. Int. J. Oncol. 2003; 22:1161-8.
- Yayoshi-Yamamoto S, Taniuchi I and Watanabe T. FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages. Mol. Cell. Biol. 2000; 20: 6872-81.
- Favaro PM, Traina F, Vassallo J, et al. High expression of FMNL1 protein in T non-Hodgkin's lymphomas. Leuk. Res. 2006; 30:735-8.
- Gomez TS, Kumar K, Medeiros RB, et al. Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse. Immunity 2007; 26:177-90.
FRL1 Antibody is supplied in PBS containing 0.02% sodium azide.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Rabbit polyclonal FRL1 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human FRL1.
The immunogen is located within the last 50 amino acids of FRL1.
752
formin-like 1
FMNL1
homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
121 kDa
NP_005883
33356148
FRL1 Antibody is affinity chromatography purified via peptide column.
Homeostasis
FRL1 antibody is human, mouse and rat reactive. Three alternatively spliced transcript variants have been observed
O95466
Optimal dilutions for each application to be determined by the researcher.