ProSci

CHCHD6 Antibody

Product Code:
 
PSI-7133
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
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Western blot analysis of CHCHD6 in SK-N-SH cell lysate with CHCHD6 antibody at 1 μg/mL.
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Western blot analysis of CHCHD6 in SK-N-SH cell lysate with CHCHD6 antibody at 1 μg/mL.

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CodeSizePrice
PSI-7133-0.02mg0.02mg£150.00
Quantity:
PSI-7133-0.1mg0.1mg£449.00
Quantity:
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Further Information

Additional Names:
CHCHD6 Antibody: CHCM1, PPP1R23, CHCM1, Coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrial, Coiled coil helix cristae morphology protein 1
Application Note:
CHCHD6 antibody can be used for detection of CHCHD6 by Western blot at 1 - 2 μg/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
CHCHD6 Antibody: CHCHD6 is a member of a family of proteins containing a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain and has been observed in a complex with the mitochondrial proteins mitofilin, SAM50, metaxins 1 and 2, and CHCHD3. CHCHD6 knockdown causes severe defects in mitochondrial cristae morphology as well as reductions in cell growth, ATP production and oxygen consumption. This decrease of CHCHD6 also led to a reduction in mitofilin protein levels, while a knockdown of mitofilin resulted in a reduced level of CHCHD6, suggesting coordinate regulation between these two proteins. CHCHD6 knockdown in human cancer cells enhances their sensitivity to genotoxic anticancer drugs, suggesting that CHCHD6 may be a potential therapeutic anti-tumor target.
Background References:
  • Xie J, Marusich MF, Souda P, et al. The mitochondrial inner membrane protein Mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11. FEBS Lett. 2007; 581:3545-9.
  • An J, Shi J, He Q, et al. CHCM1/CHCHD6, novel mitochondrial protein linked to regulation of mitofilin and mitochondrial cristae morphology. J. Biol. Chem. 2012; 287:7411-26.
Buffer:
CHCHD6 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Rabbit polyclonal CHCHD6 antibody was raised against a 17 amino acid peptide near the amino terminus of human CHCHD6.

The immunogen is located within amino acids 20 - 70 of CHCHD6.
NCBI Gene ID #:
84303
NCBI Official Name:
coiled-coil-helix-coiled-coil-helix domain containing 6
NCBI Official Symbol:
CHCHD6
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 26 kDa
Protein Accession #:
NP_115719
Protein GI Number:
14150134
Purification:
CHCHD6 Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
SPECIFICITY:
CHCHD6 is predicted to not cross-react to other members of the CHCHD family.
Swissprot #:
Q9BRQ6
User NOte:
Optimal dilutions for each application to be determined by the researcher.