ProSci

GRINA Antibody

Product Code:
 
PSI-7147
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
1 / 1
Western blot analysis of GRINA in human testis tissue lysate with GRINA antibody at (A) 1 and (B) 2 μg/mL.
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Western blot analysis of GRINA in human testis tissue lysate with GRINA antibody at (A) 1 and (B) 2 μg/mL.

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CodeSizePrice
PSI-7147-0.02mg0.02mg£150.00
Quantity:
PSI-7147-0.1mg0.1mg£449.00
Quantity:
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Further Information

Additional Names:
GRINA Antibody: LFG1, HNRGW, TMBIM3, NMDARA1, LFG1, Protein lifeguard 1, NMDA receptor glutamate-binding subunit
Application Note:
GRINA antibody can be used for detection of GRINA by Western blot at 1 - 2 μg/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
GRINA Antibody: The transmembrane BAX inhibitor motif (TMBIM) family of proteins includes the founder member TMBIM6/BI-1, TMBIM1/RECS1 (responsive to centrifugal force and shear stress gene 1 protein), TMBIM2/LFG (life guard), TMBIM3/GRINA (glutamate receptor ionotropic NMDA protein 1), TMBIM4/GAAP (Golgi anti-apoptotic-associated protein), and TMBIM5/GHTIM (growth hormone-inducible transmembrane protein). They are highly conserved in mammals and zebrafish and contain a conserved BAX inhibitor-1 motif. GRINA is expressed in the brain and is a potential apoptotic regulator.
Background References:
  • Yamaji T, Nishikawa K and Hanada K et al. Transmembrane BAX inhibitor motif containing (TMBIM) family proteins perturbs a trans-Golgi network enzyme, Gb3 synthase, and reduces Gb3 biosynthesis. J. Biol. Chem. 2010; 285:35505-18.
  • Nielsen JA, Chambers MA, Romm E, et al. Mouse transmembrane BAX inhibitor motif 3 (Tmbim3) encodes a 38 kDa transmembrane protein expressed in the central nervous system. Mol. Cell. Biochem. 2011; 357:73-81.
  • Rojas-Rivera D, Armis?n R, Colombo A, et al. TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis. Cell Death Differ. 2012; 19:1013-26.
Buffer:
GRINA Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse: (94%), Rat: (94%), Bovine: (83%)
Immunogen:
Rabbit polyclonal GRINA antibody was raised against an 18 amino acid peptide near the center of human GRINA.

The immunogen is located within amino acids 110 - 160 of GRINA.
NCBI Gene ID #:
2907
NCBI Official Name:
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
NCBI Official Symbol:
GRINA
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 41 kDa
Protein Accession #:
NP_001009184
Protein GI Number:
57165375
Purification:
GRINA Antibody is affinity chromatography purified via peptide column.
Research Area:
Apoptosis
SPECIFICITY:
GRINA antibody is predicted to not cross-react with other members of the TMBIM family.
Swissprot #:
Q7Z429
User NOte:
Optimal dilutions for each application to be determined by the researcher.