ProSci

TREM1 Antibody

Product Code:
 
PSI-7185
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
1 / 1
Western blot analysis of TREM1 in 293 cell lysate with TREM1 antibody at (A) 1 and (B) 2 μg/mL.
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Western blot analysis of TREM1 in 293 cell lysate with TREM1 antibody at (A) 1 and (B) 2 μg/mL.

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CodeSizePrice
PSI-7185-0.02mg0.02mg£150.00
Quantity:
PSI-7185-0.1mg0.1mg£449.00
Quantity:
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Further Information

Additional Names:
TREM1 Antibody: CD354, TREM-1, Triggering receptor expressed on myeloid cells 1, Triggering receptor expressed on monocytes 1
Application Note:
TREM1 antibody can be used for detection of TREM1 by Western blot at 1 - 2 μg/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
TREM1 Antibody: TREM1 (triggering receptor expressed on myeloid cells 1) is a receptor belonging to the Ig superfamily that amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. It is thought that TREM1 other related TREM proteins such as TREM2 act to modulate the inflammatory response. TREM1 has also been linked to inflammatory bowel disease resulting in enhanced production of TNF, IL-6, IL-8, and MCP-1.
Background References:
  • Bouchon A, Facchetti F, Weigand MA, et al. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature 2001; 410:1103-7.
  • Ford JW and McVicar DW. TREM and TREM-like receptors in inflammation and disease. Curr. Opin. Immunol. 2009; 21:38-46
  • Schenk M, Bouchon A, Seibold F, et al. TREM-1-expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases. J. Clin. Invest. 2007; 117:3097-106.
Buffer:
TREM1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse: (71%)
Immunogen:
Rabbit polyclonal TREM1 antibody was raised against a 17 amino acid peptide near the amino terminus of human TREM1.

The immunogen is located within the first 50 amino acids of TREM1.
NCBI Gene ID #:
54210
NCBI Official Name:
triggering receptor expressed on myeloid cells
NCBI Official Symbol:
TREM1
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 26 kDa
Protein Accession #:
NP_061113
Protein GI Number:
8924262
Purification:
TREM1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Innate Immunity
Swissprot #:
Q9NP99
User NOte:
Optimal dilutions for each application to be determined by the researcher.