ProSci

VTCN1 Antibody

Product Code:
 
PSI-7189
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
1 / 1
Western blot analysis of VTCN1 in EL4 cell lysate with VTCN1 antibody at 1 μg/mL.
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Western blot analysis of VTCN1 in EL4 cell lysate with VTCN1 antibody at 1 μg/mL.

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CodeSizePrice
PSI-7189-0.02mg0.02mg£150.00
Quantity:
PSI-7189-0.1mg0.1mg£449.00
Quantity:
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Further Information

Additional Names:
VTCN1 Antibody: B7X, B7H4, B7S1, B7-H4, B7h.5, VCTN1, PRO1291, UNQ659/PRO1291, V-set domain-containing T-cell activation inhibitor 1, Immune costimulatory protein B7-H4
Application Note:
VTCN1 antibody can be used for detection of VTCN1 by Western blot at 1 - 2 μg/mL.

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Background:
VTCN1 Antibody: T cell immunity plays a critical role in host immune surveillance of tumour cell growth and metastatic spread. VTCN1, also known as B7-H4, is a member of the B7 family of immune regulatory molecules. Expressed primarily on the membrane of lymphoid cells, VTCN1 is an immunoinhibitory protein that interacts with receptors on the surface of T lymphocytes, thus mediating cellular and humoral immune responses. Overexpression of VTCN1 is associated with certain malignancies, including ovarian and breast cancer, which may be a mechanism by which tumour cells suppress T cell immunity and facilitate tumour progression. VTCN1 may thus be a useful biomarker for the early detection of ovarian cancer.
Background References:
  • Flies DB and Chen L. The new B7s: playing a pivotal role in tumor immunity. J. Immunother. 2007; 30:251-60.
  • Sica GL, Choi IH, Zhu G, et al. B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. Immunity 2003; 18:849-61
  • Zang X, Loke P, Kim J, et al. B7x: a widely expressed B7 family member that inhibits T cell activation. Proc. Natl. Acad. Sci. USA 2003; 100:10388 - 92.
  • Salceda S, Tang T, Kmet M, et al. The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation. Exp. Cell Res. 2005; 306:128-41.
Buffer:
VTCN1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat: (83%)
Immunogen:
Rabbit polyclonal VTCN1 antibody was raised against an 18 amino acid peptide near the center of human VTCN1.

The immunogen is located within amino acids 70 - 120 of VTCN1.
NCBI Gene ID #:
79679
NCBI Official Name:
V-set domain containing T cell activation inhibitor 1
NCBI Official Symbol:
VTCN1
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 31 kDa
Protein Accession #:
NP_078902
Protein GI Number:
99028881
Purification:
VTCN1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Innate Immunity
Swissprot #:
Q7Z7D3
User NOte:
Optimal dilutions for each application to be determined by the researcher.