Further Information
PRKCT, nPKC-theta, MMAC1, TEP1, KPCT, PKC-theta, PKCQ, PRKCQ, PRKCT
Western Blot: 1:500, Immunohistochemistry: 1:50~1:100
This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR)-mediated T-cell activation, but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-κ-B in mature T lymphocytes. Required for interleukin-2 (IL2) production. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
- Xu ZB, et al. (2004) J Biol Chem 279:50401-50409Thebault S, et al. (2004) Mol Immunol 40: 931-942
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
PKCtheta (Phospho-Ser695) antibody was raised against a peptide sequence around phosphorylation site of serine 695 (N-F-S (p) -F-M) derived from Human PKCΘ.
Phospho-Specific
5588
protein kinase C, theta
PRKCQ
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
80 kDa
NP_006248.1
5453976
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Phospho-Specific,Apoptosis,Cancer
This antibody detects endogenous level of PKCΘ only when phosphorylated at serine 695.
Q04759