ProSci

GAT-1 Antibody

Product Code:
 
PSI-50-215
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Mouse
  • Rat
Applications:
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
 
GAT-1 antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.
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Western blot of rat hippocampal homogenate showing specific immunolabeling of the~ 67k GAT-1 protein.
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Western blot of rat hippocampal homogenate showing specific immunolabeling of the~ 67k GAT-1 protein.

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PSI-50-215-0.1mL0.1mL£686.00
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Further Information

Application Note:
The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will also react with mouse tissue based on the fact that this species has 100% homology with the amino acid sequence used as antigen.
Background:
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl? channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-1, the most abundant of the transporters, is found predominantly in neurons, but also in some specialized glia (Minelli et al., 1995). GAT-1 is thought to play a key role in epileptogenesis (Zhao et al. 2003).
Background References:
  • Minelli A, Brecha NC, Karschin C, DeBiasi S, Conti F (1995) GAT-1, a high-affinity GABA plasma membrana transporter, is localizad to neurons and astroglia int he cerebral cortex. J. Neurosci. 15(11):7734-7746.
  • Zhao WJ, Ma YH, Fei J, Mei ZT, Guo LH (2003) Increase in drug-induced seizure susceptibility of transgenic mice overexpressing GABA transporter 1. Acta Pharmacol. Sin. 24(10):991-5.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Peptide corresponding to amino acid residues from the C-terminal region of rat GAT-1.
NCBI Gene ID #:
79212
NCBI Official Name:
solute carrier family 6 (neurotransmitter transporter), member 1
NCBI Official Symbol:
Slc6a1
NCBI Organism:
Rattus norvegicus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
67
Protein Accession #:
P23978
Protein GI Number:
128609
Purification:
Affinity Purified
Swissprot #:
P23978
User NOte:
Optimal dilutions for each application to be determined by the researcher.