ProSci

GAT-2 Antibody

Product Code:
 
PSI-50-216
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Mouse
  • Rat
Application:
 
Immunohistochemistry (IHC)
Storage:
 
GAT-2 antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.
 

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PSI-50-216-0.1mL0.1mL£686.00
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Further Information

Application Note:
The antibody has been directly tested for reactivity in immunohistochemistry in rat cortex and retinal sections. It is anticipated that the antibody will also work in mouse sections based on the fact that this species has 100% homology with the amino acid sequence used as antigen.
Background:
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl? channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-2 is found in a wide range of neuronal and non-neuronal cells including dendrites and axon terminals as well as epithelial cells and cells forming the pia and arachnoid complex (Conti et al., 1999).
Background References:
  • Conti F, Zucharello LV, Barbaresi P, Minelli A, Brecha NC, Melone M, (1999) Neuronal, glial, and epithelial localization of gamma-aminobutyric acid transporter 2, a high affinity gamma-aminobutyric acid plasma membrane transporter, in the cerebral cortex and neighboring structures. J. Comp Neurol. 409(3): 482-494.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Peptide corresponding to amino acid residues from the C-terminal region of rat GAT-2.
NCBI Gene ID #:
171163
NCBI Official Name:
solute carrier family 6 (neurotransmitter transporter), member 13
NCBI Official Symbol:
Slc6a13
NCBI Organism:
Rattus norvegicus
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
82
Protein Accession #:
P31646
Protein GI Number:
400624
Purification:
Affinity Purified
Swissprot #:
P31646
User NOte:
Optimal dilutions for each application to be determined by the researcher.