ProSci

Microtubule Associate Protein 2 Antibody

Product Code:
 
PSI-50-252
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Chicken
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Bovine (Cattle)
  • Human
  • Mouse
  • Rat
Applications:
  • Immunofluorescence (IF)
  • Western Blot (WB)
Storage:
 
Microtubule Associate Protein 2 antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.
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Western blot of rat cortex lysate showing specific immunolabeling of the ~280k MAP2 protein. <br><br> <b>Below:</b> Mixed neuron/glial cultures. The perikarya and dendrites of neurons are strongly and specifically stained with the MAP2 antibody (red). Cell nuclei are visualized with DAPI DNA stain.
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Western blot of rat cortex lysate showing specific immunolabeling of the ~280k MAP2 protein. <br><br> <b>Below:</b> Mixed neuron/glial cultures. The perikarya and dendrites of neurons are strongly and specifically stained with the MAP2 antibody (red). Cell nuclei are visualized with DAPI DNA stain.

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PSI-50-252-0.1mL0.1mL£626.00
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Further Information

Background:
Microtubules are 25nm diameter protein rods found in most kinds of eukaryotic cells. They are polymerized from a dimeric subunit made of one a subunit and one b tubulin subunit. Microtubules are associated with a family of proteins called microtubule associated proteins (MAPs), which includes the protein τ and a group of proteins referred to as MAP1, MAP2, MAP3, MAP4 and MAP5 (Kindler & Gardner 1994). MAP2 is made up of two ~280 kDa apparent molecular weight bands referred to as MAP2a and MAP2b. A third lower molecular weight form, usually called MAP2c, corresponds to a pair of protein bands running at ~70 kDa on SDS-PAGE gels. All these MAP2 forms are derived from a single gene by alternate transcription, and all share a C-terminal sequence which includes either three or four microtubule binding peptide sequences, which are very similar to those found in the related microtubule binding protein τ. MAP2 isoforms are expressed only in neuronal cells and specifically in the perikarya and dendrites of these cells. MAP2 has been recently shown to be the specific receptor for the neurosteroid pregnenolone (Fontaine-Lenore V. et al., 2006).
Background References:
  • Kindler S, Gardner CC (1994) Four repeat MAP2 isoforms in human and rat brain. Brain Res Mol Brain Res. 26(1-2):218-224.
  • Fontaine-Lenore V, Chambraud B, Fellous A, David S, Duchossoy Y, Baulieu EE, Robel P (2006) Microtubule-associated protein 2 (MAP2) is a neurosteroid. Proc Natl Acad Sci USA 103(12):4711-6.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Bovine MAP2 isolated from brain by the GTP microtubule cycling method.
NCBI Gene ID #:
4133
NCBI Official Name:
microtubule-associated protein 2
NCBI Official Symbol:
MAP2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
280
Protein Accession #:
P11137
Protein GI Number:
215274255
Purification:
Total IgY fraction
Research Area:
Homeostasis
SPECIFICITY:
Specific for the ~ 280k MAP2 protein.
Swissprot #:
P11137
User NOte:
Optimal dilutions for each application to be determined by the researcher.