Further Information
ESR1, DKFZp686N23123, ER, ESR, ESRA, Era, NR3A1, ESTRR
ESR1 antibody can be used for detection of ESR1 by ELISA at 1:62500. ESR1 antibody can be used for detection of ESR1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Hairy/enhancer of split-related proteins, such as HEY1, are basic helix-loop-helix (bHLH) transcription factors implicated in cell fate decision and boundary formation. HEY genes are direct transcriptional targets of the Notch signaling pathways in Drosophila and vertebrates. This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.
- Giegling, I., (2008) Psychiatry Res 160 (1), 1-7.
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
batch dependent
Unconjugated
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ESR1.
2099
estrogen receptor 1
ESR1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
66 kDa
NP_000116
62821794
Antibody is purified by peptide affinity chromatography method.
Transcription ,Cell Cycle ,Cancer ,Signal Transduction ,Primary ///Immunology ,
P03372
Optimal dilutions for each application to be determined by the researcher.