Further Information
UGT1A4, HUG-BR2, UDPGT, UGT1D, UGT-1D, UGT1.4, UGT1-04, UDPGT 1-4
UGT1A4 antibody can be used for detection of UGT1A4 by ELISA at 1:312500. UGT1A4 antibody can be used for detection of UGT1A4 by western blot at 1.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
UGT1A4 is an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins.This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins.
- Kaku, T., (2004) Biochem. Pharmacol. 67 (11), 2093-2102.
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
batch dependent
Unconjugated
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human UGT1A4.
54657
UDP glucuronosyltransferase 1 family, polypeptide A4
UGT1A4
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
57 kDa
NP_009051
6005930
Antibody is purified by peptide affinity chromatography method.
Membrane ,Signal Transduction
P22310
Optimal dilutions for each application to be determined by the researcher.