Antibody Clonality:
Polyclonal
Applications:- Immunohistochemistry (IHC)
- Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.
1 / 2
![Western blot analysis of lysed extracts from HeLa and HT29 cells using CREB (Ab-129). Western blot analysis of lysed extracts from HeLa and HT29 cells using CREB (Ab-129).](https://www.prosci-inc.com/static-images/79-391.jpg)
2 / 2
![Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using CREB (Ab-129). Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using CREB (Ab-129).](https://www.prosci-inc.com/static-images/79-391a.jpg)
❮❯No additional charges, what you see is what you pay! *
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available!
Contact us to find what you can save.
This product comes from:
United States.
Typical lead time:
14-21 working days.
Contact us for more accurate information.
- Further Information
- Documents
- Show All
Further Information
CREB, IKKB, CREB-1, CREB1
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
CREB1 is a transcription factor that is a member of the bZIP family of DNA binding proteins. It binds as a homodimer to the CRE (cAMP-Responsive Element), an octameric palindrome containing a conserved core sequence, 5-prime-TGACG-3-prime. It consists of two transcript variants encoding respective isoforms produced by alternate splicing. It is mapped to 2q32.3-q34 . It is phosphorylated by several protein kinases and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. CREB1 is crucial for the consolidation of long-term conditioned fear memories, but not for encoding, storage, or retrieval of these memories. It is required for the stability of reactivated or retrieved conditioned fear memories .
- Chrystelle V. Garat, et al. (2006) Mol. Cell. Biol ; 26: 4934 - 4948. Lilah Rothem, et al. (2004) Mol. Pharmacol ; 66: 1536 - 1543. Darren R. Tyson, et, al. (2002) Endocrinology; 143: 674. Kyung-Woo Park, et al. (2003) Arterioscler. Thromb. Vasc. Biol ; 23: 1364.
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
CREB (Ab-129) antibody was raised against a peptide sequence around aa.127~131 (I-L-S-R-R) derived from Human CREB.
1385
cAMP responsive element binding protein 1
CREB1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
43 kDa
NP_004370.1
4758054
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Apoptosis,Cancer,Neuroscience
This antibody detects endogenous level of total CREB protein.
P16220