Antibody Clonality:
Polyclonal
Applications:- Immunofluorescence (IF)
- Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.
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![Western blot analysis of lysed extracts from 293 and MCF cells using FLT3 (Ab-591). Western blot analysis of lysed extracts from 293 and MCF cells using FLT3 (Ab-591).](https://www.prosci-inc.com/static-images/79-572.jpg)
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![Immunofluorescence staining of methanol-fixed HeLa cells using FLT3 (Ab-591). Immunofluorescence staining of methanol-fixed HeLa cells using FLT3 (Ab-591).](https://www.prosci-inc.com/static-images/79-572b.jpg)
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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Further Information
FLK2, STK1, CD135, FLK-2, CDKN6, FLT-3, FLT3, STK-1
Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200
FLT3 encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
- Sekine S et, al. (2008) J Immunol. ;180 (12): 8126-34Pratz K et, al. (2008) Leuk Lymphoma. 2008 ;49 (5): 852-63. Al Shaer L et, al. (2008) Br J Haematol. 141 (4): 483-93.
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
FLT3 (Ab-591) antibody was raised against a peptide sequence around aa.589~593 (Y-F-Y-V-D) derived from Human FLT3.
2322
fms-related tyrosine kinase 3
FLT3
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
130, 160 kDa
NP_004110.2
121114304
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Other
This antibody detects endogenous level of total FLT3 protein.
P36888