ProSci

VASP Antibody

Product Code:
 
PSI-79-198
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
 
Store antibody at -20˚C for up to one year.
1 / 2
Western blot analysis of lysed extracts from C6 cells untreated or treated with PMA using VASP (Phospho-Ser157).
2 / 2
Immunohistochemical analysis of paraffin-embedded human tonsil carcinoma tissue using VASP (Phospho-Ser157).
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Western blot analysis of lysed extracts from C6 cells untreated or treated with PMA using VASP (Phospho-Ser157).
Immunohistochemical analysis of paraffin-embedded human tonsil carcinoma tissue using VASP (Phospho-Ser157).

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PSI-79-198-0.1mg0.1mg£488.00
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Further Information

Additional Names:
STAT5,
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Background:
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation.
Background References:
  • Zhao WM, et al. (2001) EMBO J 20 (9): 2315-2325. Millard TH, et al. (2005) EMBO J 24 (2): 240-250. K?hnel K, et al. (2004) Proc Natl Acad Sci U S A 101 (49): 17027-17032. Haffner C, et al. (1995) EMBO J 14 (1): 19-27. Ramesh N, et al. (1997) Proc Natl Acad Sci U S A 94 (26): 14671-14676.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
VASP (Phospho-Ser157) antibody was raised against a peptide sequence around phosphorylation site of serine 157 (R-V-S (p) -N-A) derived from Human VASP.
Modifications:
Phospho-Specific
NCBI Gene ID #:
7408
NCBI Official Name:
vasodilator-stimulated phosphoprotein
NCBI Official Symbol:
VASP
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
50 kDa
Protein Accession #:
NP_003361.1
Protein GI Number:
4507869
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Research Area:
Phospho-Specific
SPECIFICITY:
This antibody detects endogenous level of VASP only when phosphorylated at serine 157.
Swissprot #:
P50552