Further Information
TNFSF10, TL2, APO2L, CD253, TRAIL, Apo-2L
TNFSF10 antibody can be used for detection of TNFSF10 by ELISA at 1:62500. TNFSF10 antibody can be used for detection of TNFSF10 by western blot at 1.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
TNFSF10 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3.
- Wu, Y.Y., et al., (2004) World J. Gastroenterol. 10 (16), 2334-2339.
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
batch dependent
Unconjugated
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human TNFSF10.
8743
tumor necrosis factor (ligand) superfamily, member 10
TNFSF10
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
33 kDa
NP_003801
4507593
Antibody is purified by peptide affinity chromatography method.
Membrane ,Cancer ,Signal Transduction ,Immunology ,Primary ///Apoptosis ,
P50591
Optimal dilutions for each application to be determined by the researcher.