Antibody Clonality:
Polyclonal
Applications:- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
XKR8 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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Further Information
XKR8 Antibody: XRG8, hXkr8, XRG8, XK-related protein 8
XKR8 antibody can be used for detection of XKR8 by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
The XK Kell blood group complex subunit-related family member 8 (XKR8) is a member of a family of proteins that promote the phagocytosis of dying cells by altering the phospholipid distribution of the plasma membrane (1). XKR8 is thought to be a ?scramblase?, an enzyme that eliminates the asymmetry of phospholipid distribution in the plasma membrane. In apoptotic cells, XKR8 promotes the cell-surface exposure of phosphatidylserine (PtdSer) which serves as a signal for phagocytosis (1,2).
- Suzuki J, Denning DP, Imanishi E, et al. Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells. Science 2013; 341:403-6.
- Wang X, Wu YC, Fadok VA, et al. Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12. Science 2003; 302:1563-6.
XKR8 antibody is supplied in PBS containing 0.02% sodium azide.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
XKR8 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human XKR8.
The immunogen is located within the last 50 amino acids of XKR8.
55113
XK, Kell blood group complex subunit-related family, member 8
XKR8
homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 43 kDa
Observed: 47 kDa
NP_060523
24431977
XKR8 antibody is affinity chromatography purified via peptide column.
Apoptosis
XKR8 antibody is human reactive. At least two isoforms are known to exist; this antibody will detect both isoforms.
Q9H6D3
Optimal dilutions for each application to be determined by the researcher.