AdipoGen Life Sciences

Z-Leu-Leu-Leu-AMC

Product Code:
 
AG-CP3-0019
Product Group:
 
Inhibitors and Activators
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
-20°C
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Chemical Structure
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Chemical Structure

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AG-CP3-0019-M0011 mg£40.00
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AG-CP3-0019-M0055 mg£100.00
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Further Information

Alternate Names/Synonyms:
Z-LLL-AMC; Proteasome Substrate I
Appearance:
Solid lyophilized powder.
CAS:
152015-61-7
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Avoid freeze/thaw cycles.Protect from light.
InChi:
InChI=1S/C36H48N4O7/c1-21(2)15-28(33(42)37-26-13-14-27-24(7)18-32(41)47-31(27)19-26)38-34(43)29(16-22(3)4)39-35(44)30(17-23(5)6)40-36(45)46-20-25-11-9-8-10-12-25/h8-14,18-19,21-23,28-30H,15-17,20H2,1-7H3,(H,37,42)(H,38,43)(H,39,44)(H,40,45)/t28-,29-,30-/m0/s1
InChiKey:
MBZJQSNQQJWUBH-DTXPUJKBSA-N
Long Description:
Chemical. CAS: 152015-61-7. Formula: C36H48N4O7. MW: 648.8. Fluorogenic substrate for measuring the chymotrypsin-like peptidase activity of the 20S proteasome. Excitation: 345nm. Emission: 445nm. This substrate is useful for inhibitor screening and kinetic analysis.
MDL:
MFCD01074988
Molecular Formula:
C36H48N4O7
Molecular Weight:
648.8
Other data:
Use: Reaction conditions will need to be optimized for each specific application.
Package Type:
Vial
Product Description:
Fluorogenic substrate for measuring the chymotrypsin-like peptidase activity of the 20S proteasome. Excitation: 345nm. Emission: 445nm. This substrate is useful for inhibitor screening and kinetic analysis.
Purity:
>95% (HPLC)
Sequence:
Z-Leu-Leu-Leu-7-amido-4-methylcoumarin
SMILES:
CC(C)C[C@H](NC(=O)OCC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NC1=CC=C2C(C)=CC(=O)OC2=C1
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.

References

The antitumor drug aclacinomycin A, which inhibits the degradation of ubiquitinated proteins, shows selectivity for the chymotrypsin-like activity of the bovine pituitary 20 S proteasome: M.E. Figueiredo-Pereira, et al.; J. Biol. Chem. 271, 16455 (1996) | Transforming growth factor-beta inhibition of proteasomal activity: a potential mechanism of growth arrest: L. Tadlock, et al.; Am. J. Physiol. Cell Physiol. 285, C277 (2003) | Involvement of the ubiquitin pathway in decreasing Ku70 levels in response to drug-induced apoptosis: V. Gama, et al.; Exp. Cell. Res. 312, 488 (2006)