Z-Leu-Arg-Gly-Gly-AMC
Product Code:
AG-CP3-0023
AG-CP3-0023
Regulatory Status:
RUO
RUO
Shipping:
Ambient
Ambient
Storage:
-20°C
-20°C
No additional charges, what you see is what you pay! *
Code | Size | Price |
---|
AG-CP3-0023-M001 | 1 mg | £45.00 |
Quantity:
AG-CP3-0023-M005 | 5 mg | £105.00 |
Quantity:
Prices exclude any Taxes / VAT
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: Switzerland.
Typical lead time: 7-10 working days.
Contact us for more accurate information.
Typical lead time: 7-10 working days.
Contact us for more accurate information.
- Further Information
- Documents
- References
- Related Products
- Show All
Further Information
Alternate Names/Synonyms:
Z-LRGG-AMC . TFA; UCH Substrate
Appearance:
Solid lyophilized powder.
CAS:
167698-68-2 (free base)
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Avoid freeze/thaw cycles.Protect from light.
InChi:
InChI=1S/C34H44N8O8.C2HF3O2/c1-20(2)14-26(42-34(48)49-19-22-8-5-4-6-9-22)32(47)41-25(10-7-13-37-33(35)36)31(46)39-17-28(43)38-18-29(44)40-23-11-12-24-21(3)15-30(45)50-27(24)16-23;3-2(4,5)1(6)7/h4-6,8-9,11-12,15-16,20,25-26H,7,10,13-14,17-19H2,1-3H3,(H,38,43)(H,39,46)(H,40,44)(H,41,47)(H,42,48)(H4,35,36,37);(H,6,7)/t25-,26-;/m0./s1
InChiKey:
OHFBLWHOBJRDAB-CCQIZPNASA-N
Long Description:
Chemical. CAS: 167698-68-2 (free base). Formula: C34H44N8O8 . C2HF3O2. MW: 692.8 . 114.0. Fluorogenic tetrapeptide substrate for ubiquitin C-terminal hydrolases (UCHs, e.g. UCHL3) and isopeptidase T. LRGG is the preferred substrate sequence of the human deSUMOylating enzymes SENP6 and SENP7. Excitation: 380nm. Emission: 460nm.
MDL:
MFCD00797527
Molecular Formula:
C34H44N8O8 . C2HF3O2
Molecular Weight:
692.8 . 114.0
Other data:
Use: Add from DMSO stock directly to in vitro or in vivo assays at desired concentration. Typical concentrations range from 10-100µM.
Package Type:
Vial
Product Description:
Fluorogenic tetrapeptide substrate for ubiquitin C-terminal hydrolases (UCHs, e.g. UCHL3) and isopeptidase T. LRGG is the preferred substrate sequence of the human deSUMOylating enzymes SENP6 and SENP7 [3]. Excitation: 380nm. Emission: 460nm.
Purity:
>95% (HPLC)
Sequence:
Z-Leu-Arg-Gly-Gly-7-amido-4-methylcoumarin
SMILES:
CC(C)C[C@H](NC(=O)OCC1=CC=CC=C1)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NCC(=O)NC1=CC2=C(C=C1)C(C)=CC(=O)O2
Solubility Chemicals:
Soluble in 10% acetic acid.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.
References
The papain-like protease from the severe acute respiratory syndrome coronavirus is a deubiquitinating enzyme: H.A. Lindner, et al.; J. Virol. 79, 15199 (2005) | Biochemical characterization of USP7 reveals post-translational modification sites and structural requirements for substrate processing and subcellular localization: A. Fernandez-Montalvan, et al.; FEBS J. 274, 4256 (2007) | Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family: M. Drag, et al.; Biochem. J. 409, 461 (2008) | Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features: J. Lei, et al.; Antivir. Res. 109, 72 (2014)
Related Products
Product Name | Product Code | Supplier | Ac-Arg-Leu-Arg-AMC | AG-CP3-0013 | AdipoGen Life Sciences | Summary Details | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Boc-Leu-Arg-Arg-AMC | AG-CP3-0014 | AdipoGen Life Sciences | Summary Details | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Z-Leu-Leu-Nva-CHO [MG-115] | AG-CP3-0015 | AdipoGen Life Sciences | Summary Details | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Suc-Leu-Leu-Val-Tyr-AMC | AG-CP3-0016 | AdipoGen Life Sciences | Summary Details | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Z-Leu-Leu-Leu-AMC | AG-CP3-0019 | AdipoGen Life Sciences | Summary Details | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Z-Leu-Leu-Glu-AMC | AG-CP3-0022 | AdipoGen Life Sciences | Summary Details | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||