ProSci

CD123 Antibody [6H6] (PE)

Product Code:
 
PSI-76-858
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG1, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
6H6
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Flow Cytometry
Storage:
 
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
 

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PSI-76-858-25tests25tests£348.00
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Further Information

Additional Names:
IL3R, CD123, IL3RX, IL3RY, IL3RAY, hIL-3Ra, IL3RA
Background:
The 6H6 monoclonal antibody specifically reacts with human CD123, the alpha chain subunit of the IL-3 receptor. CD123?s affinity to IL-3 is low, but increases when associated with CD131. It can be found on basophils, dendritic cells, macrophages, and mast cells.
Background References:
  • Agrawal, L., Maxwell, C. R., Peters, P. J., Clapham, P. R., Liu, S. M., Mackay, C. R., Strayer, D. S. (2009). Complexity in human immunodeficiency virus type 1 (HIV-1) co-receptor usage: roles of CCR3 and CCR5 in HIV-1 infection of monocyte-derived macrophages and brain microglia.Journal of General Virology,90(3), 710-722.
  • Heath, H., Qin, S., Rao, P., Wu, L., LaRosa, G., Kassam, N., ... Mackay, C. R. (1997). Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody.Journal of Clinical Investigation,99(2), 178.
  • Choe, H., Farzan, M., Sun, Y., Sullivan, N., Rollins, B., Ponath, P. D., ... Sodroski, J. (1996). The -beta--chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.Cell,85(7), 1135-1148.
Buffer:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Conjugate:
PE
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
3563
NCBI Official Name:
interleukin 3 receptor, alpha (low affinity)
NCBI Official Symbol:
IL3RA
NCBI Organism:
Homo sapiens
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Area:
Stem Cell,Chemokines & Cytokines, Growth Factors
SPECIFICITY:
The 6H6 monoclonal antibody specifically reacts with human CD123, the alpha chain subunit of the IL-3 receptor.
Swissprot #:
P26951
User NOte:
Optimal dilutions for each application to be determined by the researcher.