ProSci

CD106 Antibody [STA] (PE)

Product Code:
 
PSI-76-884
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG1, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
STA
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Flow Cytometry
Storage:
 
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
 

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PSI-76-884-25tests25tests£344.00
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Further Information

Additional Names:
END, HHT1, ORW1, ENG
Background:
The STA monoclonal antibody specifically reacts with human CD106, a 110 kDA glycoprotein also named Vascular Cell Adhesion Molecule-1 (VCAM-1) and INCAM-110. Its expression is induced by inflammation stimuli and cytokines and it is found mainly on activated vascular endothelium. CD106 is also found on subsets of macrophages, stromal cells, dendritic cells, and myeloid lineage cells. The integrins that bind CD106 are CD49d/CD29 and LPAM-1, and it is involved in cell adhesion, transmigration and T cell proliferation.
Background References:
  • Elshal, M. F., Khan, S. S., Takahashi, Y., Solomon, M. A., McCoy, J. P. (2005). CD146 (Mel-CAM), an adhesion marker of endothelial cells, is a novel marker of lymphocyte subset activation in normal peripheral blood.Blood,106(8), 2923-2924.
  • Shih, I. M. (1999). The role of CD146 (MelCAM) in biology and pathology.The Journal of pathology,189(1), 4-11.
  • Solovey, A. N., Gui, L., Chang, L., Enenstein, J., Browne, P. V., Hebbel, R. P. (2001). Identification and functional assessment of endothelial P1H12.Journal of Laboratory and Clinical Medicine,138(5), 322-331.
Buffer:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Conjugate:
PE
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
2022
NCBI Official Name:
endoglin
NCBI Official Symbol:
ENG
NCBI Organism:
Homo sapiens
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Area:
Immunology
SPECIFICITY:
The STA monoclonal antibody specifically reacts with human CD106, a 110 kDA glycoprotein also named Vascular Cell Adhesion Molecule-1 (VCAM-1) and INCAM-110.
Swissprot #:
P17813
User NOte:
Optimal dilutions for each application to be determined by the researcher.