ProSci

CD127 Antibody [RDR5] (PE-Cy5)

Product Code:
 
PSI-76-927
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG1, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
RDR5
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Flow Cytometry
Storage:
 
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
 

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PSI-76-927-100tests100tests£633.00
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Further Information

Additional Names:
ILRA, CD127, IL7RA, CDW127, IL-7R-alpha, IL7R
Background:
The RDR5 monoclonal antibody specifically reacts with human CD127, a 60-90 kDA type I transmembrane glycoprotein also known as the IL-7 receptor alpha chain. CD127 binds with CD132 (gamma c) to forms the IL-7 receptor that is expressed on mature T cells and immature B cells. Since CD127 expression is downregulated in Treg cells, it can be used as a marker for differentiating them from common T cells. The binding of the RDR5 antibody can be blocked by pre-incubating the cells with human IL-7.
Background References:
  • Sallusto, F., Lenig, D., Frster, R., Lipp, M., Lanzavecchia, A. (1999). Two subsets of memory T lymphocytes with distinct homing potentials and effector functions.Nature,401(6754), 708-712.
  • Yoshida, R., Nagira, M., Imai, T., Baba, M., Takagi, S., Tabira, Y., ... Yoshie, O. (1998). EBI1-ligand chemokine (ELC) attracts a broad spectrum of lymphocytes: activated T cells strongly up-regulate CCR7 and efficiently migrate toward ELC.International immunology,10(7), 901-910.
  • Lee, N., Llano, M., Carretero, M., Ishitani, A., Navarro, F., Lpez-Botet, M., Geraghty, D. E. (1998). HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A.Proceedings of the National Academy of Sciences,95(9), 5199-5204.
Buffer:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Conjugate:
PE-Cy5
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
3575
NCBI Official Name:
interleukin 7 receptor
NCBI Official Symbol:
IL7R
NCBI Organism:
Homo sapiens
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Area:
Chemokines & Cytokines, Growth Factors
SPECIFICITY:
The RDR5 monoclonal antibody specifically reacts with human CD127, a 60-90 kDA type I transmembrane glycoprotein also known as the IL-7 receptor alpha chain.
Swissprot #:
P16871
User NOte:
Optimal dilutions for each application to be determined by the researcher.