Further Information
CD51, MSK8, VNRA, VTNR, GT, CD61, GP3A, BDPLT2, GPIIIa, BDPLT16, ITGAV, ITGB3
The 23C6 monoclonal antibody specifically reacts with the human CD51/61 molecule, known as the integrin alpha v Beta 3 complex or vitronectin receptor. The complex binds to other ligands such as CD29, fibrinogen, fibrinectin, vWf, laminin, and thrombospondin. It is expressed by endothelial cells, osteoclasts, melanoma cells, and at low levels on platelets and macrophages. The 23C6 antibody is reported to be able to block the receptors ability to form interactions with some of its ligands.
- Horton, M. A., Lewis, D., McNulty, K., Pringle, J. A., Chambers, T. J. (1985). Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens.Cancer research,45(11 Part 2), 5663-5669.
- Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.
- Chuntharapai, A., Bodary, S., Horton, M., Kim, K. J. (1993). Blocking monoclonal antibodies to alpha v-beta 3 integrin: A unique epitope of alpha v-beta 3 integrin is present on human osteoclasts.Experimental cell research,205(2), 345-352.
Phosphate-buffered aqueous solution, ph7.2.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
3685; 3690
integrin, alpha V; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGAV; ITGB3
Homo sapiens
liquid
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/?g of the protein.
Immunology,Functional Assays
The 23C6 monoclonal antibody specifically reacts with the human CD51/61 molecule, known as the integrin alpha v Beta 3 complex or vitronectin receptor.
P06756; P05106
Optimal dilutions for each application to be determined by the researcher.