Further Information
CD32, FCG2, FcGR, CD32A, CDw32, FCGR2, IGFR2, FCGR2A1, FCGR2A
The 6C4 monoclonal antibody specifically recognizes two isoforms of human CD32, Fc gamma RIIA and Fc gamma RIIB. From alternative mRNA splicing, 6 isoforms of CD32 have been reported. CD32 is a 40 kDA polymorphic transmembrane glycoprotein expressed on monocytes, macrophages, graulocytes, B cells, and platelets. The receptor has low affinity toward IgG and is involved in immunomodulation, phagocytosis, and the inflammation response. The 6C4 antibody in a rosette blocking assay is reported to inhibit Ig binding
- VELY, F., GRUEL, N., MONCUIT, J., COCHET, O., ROUARD, H., DARE, S., ... TEILLAUD, J. L. (1997). A new set of monoclonal antibodies against human Fc-gamma RII (CD32) and Fc-gamma RIII (CD16): characterization and use in various assays.Hybridoma,16(6), 519-528.
- Liebert, M. A. (1997). 6C4, 2B2, 3D3.Hybridoma,16(6).
- Bouhlal, H., Martinvalet, D., Teillaud, J. L., Fridman, C., Kazatchkine, M. D., Bayry, J., ... Kaveri, S. V. (2014). Natural Autoantibodies to Fc-gamma Receptors in Intravenous Immunoglobulins.Journal of clinical immunology, 1-8.
Phosphate-buffered aqueous solution, ph7.2.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
2212
Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2A
Homo sapiens
liquid
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/?g of the protein.
Innate Immunity,Functional Assays
The 6C4 monoclonal antibody specifically recognizes two isoforms of human CD32, Fc gamma RIIA and Fc gamma RIIB.
P12318
Optimal dilutions for each application to be determined by the researcher.