Antibody Isotype:
Mouse IgG1, kappa
Antibody Clonality:
Monoclonal
Applications:- Flow Cytometry
- Functional Study
- Immunofluorescence (IF)
- Western Blot (WB)
Storage:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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Further Information
APTL, FASL, CD178, CD95L, ALPS1B, CD95-L, TNFSF6, APT1LG1, FASLG
The NOK-1 monoclonal antibody specifically reacts with human CD178, which is the CD95 or Fas ligand. CD178 is a TNF superfamily type II transmembrane glycoprotein expressed by activated T and NK cells and is involved in Fas-mediated apoptosis of lymphocytes. CD178 is also expressed by monocytes, neutrophils, granulocytes and the parenchymal cells of the retina and cornea. The NOK-1 antibody has been reported to bind to COOH-terminus of the Fas ligand in the region associated with Fas binding.
- Kayagaki, N., Kawasaki, A., Ebata, T., Ohmoto, H., Ikeda, S., Inoue, S., ... Yagita, H. (1995). Metalloproteinase-mediated release of human Fas ligand.The Journal of experimental medicine,182(6), 1777-1783.
- Oyaizu, N., Adachi, Y., Hashimoto, F., McCloskey, T. W., Hosaka, N., Kayagaki, N., ... Pahwa, S. (1997). Monocytes express Fas ligand upon CD4 cross-linking and induce CD4+ T cells apoptosis: a possible mechanism of bystander cell death in HIV infection.The Journal of Immunology,158(5), 2456-2463.
- Villunger, A., Egle, A., Marschitz, I., Kos, M., Bck, G., Ludwig, H., ... Greil, R. (1997). Constitutive expression of Fas (Apo-1/CD95) ligand on multiple myeloma cells: a potential mechanism of tumor-induced suppression of immune surveillance.Blood,90(1), 12-20.
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
356
Fas ligand (TNF superfamily, member 6)
FASLG
Homo sapiens
liquid
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Apoptosis,Cancer,Functional Assays
The NOK-1 monoclonal antibody specifically reacts with human CD178, which is the CD95 or Fas ligand.
P48023
Optimal dilutions for each application to be determined by the researcher.