ProSci

NS3 Antibody [1B6]

Product Code:
 
PSI-36-095
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Mouse
Antibody Isotype:
 
IgG1
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
1B6
Regulatory Status:
 
RUO
Target Species:
 
Kangaroo
Applications:
  • Immunocytochemistry (ICC)
  • Western Blot (WB)
Storage:
 
Stable for at least 1 year after receipt when stored at -20˚C.
 

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PSI-36-095-100ug100ug£657.00
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Further Information

Additional Names:
Nonstructural Protein 3
Application Note:
Immunocytochemistry: (paraformaldehyde fixation) (1:50). Western Blot: (1:500).
Background:
The NS3 serine protease, in association with NS4A, is responsible for the cleavages of the Hepatitis C virus protease complexes NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication. Hepatitis C virus protease NS3-NS4A colocalizes with IPS-1/VISA/MAVS/Cardif in the mitochondrial membrane and has been shown to cleave the TLR3 adapter TRIF and Cardif to eliminate the antiviral signaling pathways. NS3-NS4A represents an important target for anti-HCV drugs.
Buffer:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant hepatitis C virus (HCV) NS3 serine protease domain.
Physical State:
Liquid
Purification:
>95% (SDS-PAGE)
Research Area:
Innate Immunity
SPECIFICITY:
Recognizes HCV NS3 (genotype 1a and 1b) (epitope mapped to NS3 aa 160-193), recognizes NS3 alone or the NS3-4A complex. Does not cross-react with HCV NS3 (genotype 2a). t
User NOte:
Optimal dilutions for each application to be determined by the researcher.