ProSci

NS5B Antibody [5B-12B7]

Product Code:
 
PSI-36-097
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Mouse
Antibody Isotype:
 
IgG2a
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
5B-12B7
Regulatory Status:
 
RUO
Target Species:
 
Kangaroo
Applications:
  • Functional Study
  • Immunocytochemistry (ICC)
  • Immunoprecipitation (IP)
Storage:
 
Stable for at least 1 year after receipt when stored at -20˚C.
 

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PSI-36-097-100ug100ug£657.00
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Further Information

Additional Names:
Nonstructural Protein 5B
Application Note:
Western Blot: (1-2ug/ml) . Optimal conditions must be determined individually for each application.
Background:
The NS3 serine protease, in association with NS4A, is responsible for the cleavages of the Hepatitis C virus protease complexes NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication. Hepatitis C virus protease NS3-NS4A colocalizes with IPS-1/VISA/MAVS/Cardif in the mitochondrial membrane and has been shown to cleave the TLR3 adapter TRIF and Cardif to eliminate the antiviral signaling pathways. NS3-NS4A represents an important target for anti-HCV drugs.
Buffer:
Liquid. In PBS containing 0.02% sodium azide.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase.
Physical State:
Liquid
Purification:
>95% (SDS-PAGE)
Research Area:
Innate Immunity,Functional Assays
SPECIFICITY:
Recognizes HCV NS5B from HCV genotype 1 (epitope mapped to NS5B aa 139-392). Does not react with genotype 2.
User NOte:
Optimal dilutions for each application to be determined by the researcher.