ProSci

Sirtuin 1 Antibody

Product Code:
 
PSI-36-283
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
Stable for at least 6 months after receipt when stored at -20˚C.
 

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PSI-36-283-100ug100ug£524.00
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Further Information

Additional Names:
SIRT1; NAD-dependent Deacetylase Sirtuin-1; SIR2-like Protein 1; SIR2L1
Application Note:
ELISA: (direct and indirect: 1:2,000-1:5,000). Western Blot: (1:2,000-1:5,000 using ECL; suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk; suggested incubation time is 1 hour at room temperature). Optimal conditions must be determined individually for each application.
Background:
Sirtuin-1 is a NAD-dependent protein deacetylase, which regulates processes such as apoptosis and muscle differentiation by deacetylating key proteins. Sirtuin-1 emerged as critical regulator of longevity and aging in several model organisms. Furthermore, a variety of age-associated diseases such as type 2 diabetes, obesity, osteoporosis, and Alzheimer?s disease are associated with sirtuins. Sirtuin-1 has been suggested as potential biomarker for tumorigenesis.
Buffer:
Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant human sirtuin 1.
NCBI Gene ID #:
23411
NCBI Official Name:
sirtuin 1
NCBI Official Symbol:
SIRT1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
7657575
Protein GI Number:
NP_001135970.1
Research Area:
Cancer,Innate Immunity,Obesity
SPECIFICITY:
Recognizes human sirtuin 1. Detects a band of ~78kDa by Western blot.
Swissprot #:
Q96EB6
User NOte:
Optimal dilutions for each application to be determined by the researcher.