ProSci

Sirtuin 2 Antibody [S2R233-1]

Product Code:
 
PSI-36-077
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Mouse
Antibody Isotype:
 
IgG2b, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
S2R233-1
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
Stable for at least 1 year after receipt when stored at -20˚C.
 

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PSI-36-077-100ug100ug£524.00
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Further Information

Additional Names:
SIRT2; NAD-dependent Deacetylase Sirtuin-2; SIR2-like protein 2; SIR2L2
Application Note:
ELISA: (direct and indirect: 1:2,000-1:5,000). Western Blot: (1:2,000-1:5,000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature). Optimal conditions must be determined individually for each application.
Background:
Sirtuin-2 is a NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of a-tubulin. It is involved in the control of mitotic exit in the cell cycle. Furthermore, a variety of age-associated diseases such as type 2 diabetes, obesity, osteoporosis, and Alzheimer?s disease are associated with sirtuins. Selective inhibition of Sirtuin-2 achieves neuroprotection and identifies Sirtuin-2 to be a potential therapeutic avenue in Huntington?s and Parkinson?s disease.
Buffer:
Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant human sirtuin 2.
NCBI Gene ID #:
22933
NCBI Official Name:
sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)
NCBI Official Symbol:
SIRT2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
13775600
Protein GI Number:
NP_036369
Research Area:
Cancer,Innate Immunity,Obesity
SPECIFICITY:
Recognizes human sirtuin 2. Detects a band of ~45kDa by Western blot.
Swissprot #:
Q8IXJ6
User NOte:
Optimal dilutions for each application to be determined by the researcher.