ProSci

Caspase-8 Antibody [C15]

Product Code:
 
PSI-36-164
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Mouse
Antibody Isotype:
 
IgG2b
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
C15
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Immunocytochemistry (ICC)
  • Immunoprecipitation (IP)
  • Western Blot (WB)
Storage:
 
Stable for at least 1 year after receipt when stored at -20˚C.
 

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PSI-36-164-100ug100ug£657.00
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Further Information

Additional Names:
Apoptotic Cysteine Protease; Apoptotic Protease Mch-5; CAP4; FADD-homologous ICE/ced-3-like Protease
Background:
Procaspase-8 belongs to the family of caspases. Binding of FasL to Fas leads to formation of a receptor complex at the cellular membrane, which was named DISC. The DISC consists of oligomerized receptors, the DD-containing adaptor molecule FADD, procaspase-8, procaspase-10 and c-FLIP. The DISC structure provides a platform for the oligomerization of procaspase-8 that allows two procaspase-8 homodimers to be in the close proximity leading to the initial activation of procaspase-8. At the first cleavage step, the N-terminal p43/p41 and the C-terminal p30 cleavage products are generated. Importantly, these cleavage products already possess catalytic activity. At the second cleavage step, p43/p41 and p30 are processed to p10 and p18, respectively, which leads to the generation of the active caspase-8 heterotetramer (p18/p10)2.
Buffer:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Concentration:
0.5 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant human caspase-8 (aa 181-478).
NCBI Gene ID #:
841
NCBI Official Name:
caspase 8, apoptosis-related cysteine peptidase
NCBI Official Symbol:
CASP8
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
15718704
Protein GI Number:
NP_001219
Purification:
>95% (SDS-PAGE)
Research Area:
Apoptosis
SPECIFICITY:
Recognizes the p18 subunit of human caspase-8.
Swissprot #:
Q14790
User NOte:
Optimal dilutions for each application to be determined by the researcher.