Antibody Clonality:
Polyclonal
Applications:- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
SLC30A8 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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Further Information
SLC30A8 Antibody: Solute carrier family 30 member 8, zinc transporter 8, ZNT8, Zn-T8
SLC30A8 antibody can be used for Western blot at 1 - 2 μg/mL. Antibody can also be used for Immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
SLC30A8 Antibody: SLC30A8 is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles and is expressed at a high level in the pancreas, particularly in islets of Langerhans, and co-localizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells (1). Allelic variants of SLC30A8 have been identified as major genetic risk factors for the development of Type 2 diabetes (2), but no genetic association has been found with Type 1 diabetes (3). SLC30A8 expression in ?-cells was found to be influenced by cytokine expression, particularly IFN-gamma and IL-1beta (4).
- Chimienti F, Devergnas S, Favier A, et al. Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules. Diabetes 2004; 53:2330-7.
- Sladek R, Rocheleau G, Rung J, et al. A genome-wide association study indentifies novel risk loci for type 2 diabetes. Science 2007; 445:881-5.
- Qu HQ, Grant SF, Bradfield JP, et al. Association analysis of type 2 diabetes Loci in type 1 diabetes. Diabetes 2008; 57:1983-6.
- Egefjord L, Jensen JL, Bang-Berthelsen CH, et al. Zinc transporter gene expression is regulated by pro-inflammatory cytokines: a potential role for zinc transporters in beta-cell apoptosis BMC Endocrine Disorders 2009; 9:7.
SLC30A8 Antibody is supplied in PBS containing 0.02% sodium azide.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
SLC30A8 antibody was raised against a peptide corresponding to 14 amino acids near the amino terminus of human SLC30A8.
169026
solute carrier family 30 member 8
SLC30A8
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 35, 41 kDa
Observed: 35, 41 kDa
NP_776250
64762489
SLC30A8 Antibody is affinity chromatography purified via peptide column.
Homeostasis
Two isoforms of SLC30A8 are known to exist; this antibody will detect both isoforms. This SLC30A8 antibody is predicted to not cross-react with other members of the SLC30 protein family.
Q8IWU4
Optimal dilutions for each application to be determined by the researcher.