Further Information
Inhibin beta A chain, Activin beta-A chain, Erythroid differentiation protein, EDF, INHBA
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IF starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
The inhibin beta A subunit joins the alpha subunit to form
a pituitary FSH secretion inhibitor. Inhibin has been shown to
regulate gonadal stromal cell proliferation negatively and to have
tumor-suppressor activity. In addition, serum levels of inhibin
have been shown to reflect the size of granulosa-cell tumors and
can therefore be used as a marker for primary as well as recurrent
disease. Because expression in gonadal and various extragonadal
tissues may vary severalfold in a tissue-specific fashion, it is
proposed that inhibin may be both a growth/differentiation factor
and a hormone. Furthermore, the beta A subunit forms a homodimer,
activin A, and also joins with a beta B subunit to form a
heterodimer, activin AB, both of which stimulate FSH secretion.
Finally, it has been shown that the beta A subunit mRNA is
identical to the erythroid differentiation factor subunit mRNA and
that only one gene for this mRNA exists in the human genome.
- Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)
- Shi, F.T., et al. J. Clin. Endocrinol. Metab. 95 (10), E172-E180 (2010) :
- Lascorz, J., et al. Carcinogenesis 31(9):1612-1619(2010)
- Jugessur, A., et al. PLoS ONE(7), E11493 (2010) :
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
This INHBA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-112 amino acids from the N-terminal region of human INHBA.
3624
Inhibin beta A chain
INHBA
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
47 kDa
P08476
124279
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cancer,Cell Cycle,Cell Cycle,Signal Transduction
P08476
Optimal dilutions for each application to be determined by the researcher.