Further Information
Angiopoietin-1 receptor, Endothelial tyrosine kinase, Tunica interna endothelial cell kinase, Tyrosine kinase with Ig and EGF homology domains-2, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2, hTIE2, p140 TEK, CD202b, TEK, TIE2, VMCM, VMCM1
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.
- Cascone, I., et al., Blood 102(7):2482-2490 (2003).
- DeBusk, L.M., et al., Arthritis Rheum. 48(9):2461-2471 (2003).
- Poncet, S., et al., Neuropathol Appl Neurobiol 29(4):361-369 (2003).
- Lee, H.J., et al., Biochem. Biophys. Res. Commun. 304(2):399-404 (2003).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Bovine
This TEK (TIE2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 758-789 amino acids from the C-terminal region of human TEK (TIE2).
7010
Angiopoietin-1 receptor
TEK
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
126 kDa
Q02763
218511853
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Cancer,Cell Cycle,Immunology,Signal Transduction
Q02763
Optimal dilutions for each application to be determined by the researcher.