Further Information
Dual specificity mitogen-activated protein kinase kinase 3, MAP kinase kinase 3, MAPKK 3, MAPK/ERK kinase 3, MEK 3, Stress-activated protein kinase kinase 2, SAPK kinase 2, SAPKK-2, SAPKK2, MAP2K3, MEK3, MKK3, PRKMK3, SKK2
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
MAP2K3 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis.
- Yustein, J.T., et al., Oncogene 22(40):6129-6141 (2003).
- Edlund, S., et al., Mol. Biol. Cell 14(2):529-544 (2003).
- Lim, S., et al., J. Biol. Chem. 277(28):25040-25046 (2002).
- Han, Q., et al., J. Biol. Chem. 277(50):48379-48385 (2002).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This MEK3 (MAP2K3) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-45 amino acids from the N-terminal region of human MEK3 (MAP2K3).
5606
Dual specificity mitogen-activated protein kinase kinase 3
MAP2K3
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
39 kDa
P46734
24638466
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Cancer,Cell Cycle,Immunology,Signal Transduction,
P46734
Optimal dilutions for each application to be determined by the researcher.