Further Information
Interleukin-12 subunit beta, IL-12B, Cytotoxic lymphocyte maturation factor 40 kDa subunit, CLMF p40, IL-12 subunit p40, NK cell stimulatory factor chain 2, NKSF2, IL12B, NKSF2
For IHC-P starting dilution is: 1:50~100
For FACS starting dilution is: 1:10~50
For WB starting dilution is: 1:1000
IL12B is a subunit of interleukin 12, a cytokine
that acts on T and natural killer cells, and has a broad array of
biological activities. Interleukin 12 is a disulfide-linked
heterodimer composed of the 40 kD cytokine receptor like subunit
encoded by this gene, and a 35 kD subunit encoded by IL12A. This
cytokine is expressed by activated macrophages that serve as an
essential inducer of Th1 cells development. This cytokine has been
found to be important for sustaining a sufficient number of
memory/effector Th1 cells to mediate long-term protection to an
intracellular pathogen. Overexpression of this gene was observed in
the central nervous system of patients with multiple sclerosis
(MS), suggesting a role of this cytokine in the pathogenesis of the
disease. The promoter polymorphism of this gene has been reported
to be associated with the severity of atopic and non-atopic asthma
in children.
- Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Miteva, L.D., et al. Rheumatol. Int. (2010) In press :
- de Heens, G.L., et al. J. Clin. Periodontol. 37(2):129-136(2010)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This IL12B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 264-290 amino acids from the C-terminal region of human IL12B.
3593
Interleukin-12 subunit beta
IL12B
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
37 kDa
P29460
266320
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cancer,Immunology,Signal Transduction
P29460
Optimal dilutions for each application to be determined by the researcher.