ProSci

c-AMPProtein Kinase Catalytic subnunit Antibody

Product Code:
 
PSI-62-618
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Antibody is used in Western blot to detect PRKACB in A375 cell lysate.
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Antibody is used in Western blot to detect PRKACB in A375 cell lysate.

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PSI-62-618-400ul400ul£626.00
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Further Information

Additional Names:
cAMP-dependent protein kinase catalytic subunit beta, PKA C-beta, PRKACB
Application Note:
For WB starting dilution is: 1:1000
Background:
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase (AMPK), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans. PRKACB is a member of the Ser/Thr protein kinase family and is a catalytic subunit of AMPK.
Background References:
  • Dwivedi, Y., et al., Biol. Psychiatry 55(3):234-243 (2004).
  • Cartier, C., et al., J. Biol. Chem. 278(37):35211-35219 (2003).
  • Higuchi, H., et al., EMBO J. 22(8):1790-1800 (2003).
  • Wu, K.J., et al., Oncogene 21(51):7872-7882 (2002).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This c-AMPProtein Kinase Catalytic subnunit antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-47 amino acids from the N-terminal region of human c-AMPProtein Kinase Catalytic subnunit.
NCBI Gene ID #:
5567
NCBI Official Name:
cAMP-dependent protein kinase catalytic subunit beta
NCBI Official Symbol:
PRKACB
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
41 kDa
Protein Accession #:
P22694
Protein GI Number:
125210
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Obesity,Signal Transduction
Swissprot #:
P22694
User NOte:
Optimal dilutions for each application to be determined by the researcher.