Further Information
Carbonic anhydrase 9, Carbonate dehydratase IX, Carbonic anhydrase IX, CA-IX, CAIX, Membrane antigen MN, P54/58N, Renal cell carcinoma-associated antigen G250, RCC-associated antigen G250, pMW1, CA9, G250, MN
For WB starting dilution is: 1:2000
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12.
- Grabmaier, K., et al., Oncogene 23(33):5624-5631 (2004). Kaluzova, M., et al., Mol. Cell. Biol. 24(13):5757-5766 (2004). Span, P.N., et al., Br. J. Cancer 89(2):271-276 (2003). Hedley, D., et al., Clin. Cancer Res. 9(15):5666-5674 (2003). Bui, M.H., et al., Clin. Cancer Res. 9(2):802-811 (2003).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This CA9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-90 amino acids from the N-terminal region of human CA9.
768
Carbonic anhydrase 9
CA9
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
50 kDa
Q16790
83300925
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Cancer,Obesity,Signal Transduction
Q16790
Optimal dilutions for each application to be determined by the researcher.