Further Information
Farnesyl pyrophosphate synthase, FPP synthase, FPS, (2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase, FDPS, FPS, KIAA1293
For WB starting dilution is: 1:1000
This gene encodes an enzyme that catalyzes the production
of geranyl pyrophosphate and farnesyl pyrophosphate from
isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The
resulting product, farnesyl pyrophosphate, is a key intermediate in
cholesterol and sterol biosynthesis, a substrate for protein
farnesylation and geranylgeranylation, and a ligand or agonist for
certain hormone receptors and growth receptors. Drugs that inhibit
this enzyme prevent the post-translational modifications of small
GTPases and have been used to treat diseases related to bone
resorption. Multiple pseudogenes have been found on chromosomes 1,
7, 14, 15, 21 and X. Multiple transcript variants encoding
different isoforms have been found for this gene.
- Ishimoto, K., et al. Biochem. J. 429(2):347-357(2010)
- Choi, H.J., et al. Yonsei Med. J. 51(2):231-238(2010)
- Li, J., et al. J. Immunol. 182(12):8118-8124(2009)
- Romanelli, M.G., et al. Genomics 93(3):227-234(2009)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This FDPS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-82 amino acids from the N-terminal region of human FDPS.
2224
Farnesyl pyrophosphate synthase
FDPS
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
48 kDa
P14324
215274250
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cancer,Obesity,Signal Transduction
P14324
Optimal dilutions for each application to be determined by the researcher.