ProSci

SILV Antibody

Product Code:
 
PSI-57-246
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in CEM cell line lysates (35ug/lane).
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Western blot analysis in CEM cell line lysates (35ug/lane).

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PSI-57-246-400ul400ul£626.00
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This product comes from: United States.
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Further Information

Additional Names:
Melanocyte protein PMEL, ME20-M, ME20M, Melanocyte protein Pmel 17, Melanocytes lineage-specific antigen GP100, Melanoma-associated ME20 antigen, P1, P100, Premelanosome protein, Silver locus protein homolog, M-alpha, 95 kDa melanocyte-specific secreted glycoprotein, P26, Secreted melanoma-associated ME20 antigen, ME20-S, ME20S, M-beta, PMEL, D12S53E, PMEL17, SILV
Application Note:
For WB starting dilution is: 1:1000
Background:
SILV plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity.
Background References:
  • Leonhardt, R.M., et al. J. Biol. Chem. 285(21):16166-16183(2010)
  • Hoashi, T., et al. FASEB J. 24(3):916-930(2010)
  • Watt, B., et al. J. Biol. Chem. 284(51):35543-35555(2009)
  • McGlinchey, R.P., et al. Proc. Natl. Acad. Sci. U.S.A. 106(33):13731-13736(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This SILV antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 412-440 amino acids from the Central region of human SILV.
NCBI Gene ID #:
6490
NCBI Official Name:
Melanocyte protein PMEL
NCBI Official Symbol:
PMEL
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
70 kDa
Protein Accession #:
P40967
Protein GI Number:
2507099
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cancer,Obesity,Signal Transduction
Swissprot #:
P40967
User NOte:
Optimal dilutions for each application to be determined by the researcher.