Further Information
Glutamate carboxypeptidase 2, Cell growth-inhibiting gene 27 protein, Folate hydrolase 1, Folylpoly-gamma-glutamate carboxypeptidase, FGCP, Glutamate carboxypeptidase II, GCPII, Membrane glutamate carboxypeptidase, mGCP, N-acetylated-alpha-linked acidic dipeptidase I, NAALADase I, Prostate-specific membrane antigen, PSM, PSMA, Pteroylpoly-gamma-glutamate carboxypeptidase, FOLH1, FOLH, NAALAD1, PSM, PSMA
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IF starting dilution is: 1:10~50
This gene encodes a type II transmembrane glycoprotein
belonging to the M28 peptidase family. The protein acts as a
glutamate carboxypeptidase on different alternative substrates,
including the nutrient folate and the neuropeptide
N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of
tissues such as prostate, central and peripheral nervous system and
kidney. A mutation in this gene may be associated with impaired
intestinal absorption of dietary folates, resulting in low blood
folate levels and consequent hyperhomocysteinemia. Expression of
this protein in the brain may be involved in a number of
pathological conditions associated with glutamate excitotoxicity.
In the prostate the protein is up-regulated in cancerous cells and
is used as an effective diagnostic and prognostic indicator of
prostate cancer. This gene likely arose from a duplication event of
a nearby chromosomal region. Alternative splicing gives rise to
multiple transcript variants encoding several different isoforms.
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Giusti, B., et al. Thromb. Haemost. 104(2):231-242(2010)
- Jugessur, A., et al. PLoS ONE(7), E11493 (2010) :
- Mlcochova, P., et al. Prostate 69(5):471-479(2009)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Mouse, Pig, Rat
This FOLH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-190 amino acids from the N-terminal region of human FOLH1.
2346
Glutamate carboxypeptidase 2
FOLH1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
84 kDa
Q04609
548615
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cancer,Obesity,Signal Transduction
Q04609
Optimal dilutions for each application to be determined by the researcher.