Further Information
Pulmonary surfactant-associated protein C, SP-C, Pulmonary surfactant-associated proteolipid SPL(Val), SP5, SFTPC, SFTP2
For IHC-P starting dilution is: 1:25
For WB starting dilution is: 1:1000
For IF starting dilution is: 1:10~50
This gene encodes the pulmonary-associated surfactant
protein C (SPC), an extremely hydrophobic surfactant protein
essential for lung function and homeostasis after birth. Pulmonary
surfactant is a surface-active lipoprotein complex composed of 90%
lipids and 10% proteins which include plasma proteins and
apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted
by the alveolar cells of the lung and maintains the stability of
pulmonary tissue by reducing the surface tension of fluids that
coat the lung. Multiple mutations in this gene have been
identified, which cause pulmonary surfactant metabolism dysfunction
type 2, also called pulmonary alveolar proteinosis due to
surfactant protein C deficiency, and are associated with
interstitial lung disease in older infants, children, and adults.
Alternatively spliced transcript variants encoding different
protein isoforms have been identified.
- Wambach, J.A., et al. Pediatr. Res. 68(3):216-220(2010)
- Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)
- Thouvenin, G., et al. Arch. Dis. Child. 95(6):449-454(2010)
- Crossno, P.F., et al. Chest 137(4):969-973(2010)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This SFTPC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 144-173 amino acids from the C-terminal region of human SFTPC.
6440
Pulmonary surfactant-associated protein C
SFTPC
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
21 kDa
P11686
131425
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cancer,Obesity,Signal Transduction
P11686
Optimal dilutions for each application to be determined by the researcher.