ProSci

CUL4B Antibody

Product Code:
 
PSI-60-941
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
1 / 2
Western Blot at 1:2000 dilution + human testis lysates Lysates/proteins at 20 ug per lane.
2 / 2
Western blot analysis of CUL4B Antibody Pab pre-incubated without(lane 1) and with(lane 2) blocking peptide in Hela cell line lysate.
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Western Blot at 1:2000 dilution + human testis lysates Lysates/proteins at 20 ug per lane.
Western blot analysis of CUL4B Antibody Pab pre-incubated without(lane 1) and with(lane 2) blocking peptide in Hela cell line lysate.

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PSI-60-941-400ul400ul£626.00
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Further Information

Additional Names:
Cullin-4B, CUL-4B, CUL4B, KIAA0695
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Background References:
  • Aggarwal, P., et al. Cancer Cell 18(4):329-340(2010)
  • Abbas, T., et al. Mol. Cell 40(1):9-21(2010)
  • Kerzendorfer, C., et al. Hum. Mol. Genet. 19(7):1324-1334(2010)
  • Gascoin-Lachambre, G., et al. Placenta 31(2):151-157(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This CUL4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-278 amino acids from the Central region of human CUL4B.
NCBI Gene ID #:
8450
NCBI Official Name:
Cullin-4B
NCBI Official Symbol:
CUL4B
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
104 kDa
Protein Accession #:
Q13620
Protein GI Number:
296439468
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle
Swissprot #:
Q13620
User NOte:
Optimal dilutions for each application to be determined by the researcher.