Further Information
Fizzy-related protein homolog, Fzr, CDC20-like protein 1, Cdh1/Hct1 homolog, hCDH1, FZR1, CDH1, FYR, FZR, KIAA1242
For WB starting dilution is: 1:1000
Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
- Olson, J.E., et al. Breast Cancer Res. Treat. 125(1):221-228(2011)
- Colombo, S.L., et al. Proc. Natl. Acad. Sci. U.S.A. 107(44):18868-18873(2010)
- Naoe, H., et al. Mol. Cell. Biol. 30(16):3994-4005(2010)
- Sigl, R., et al. J. Cell. Sci. 122 (PT 22), 4208-4217 (2009) :
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Mouse
This FZR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-81 amino acids from the N-terminal region of human FZR1.
51343
Fizzy-related protein homolog
FZR1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
55 kDa
Q9UM11
37537753
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cell Cycle
Q9UM11
Optimal dilutions for each application to be determined by the researcher.