Further Information
DNA dC->dU-editing enzyme APOBEC-3A, A3A, 354-, Phorbolin-1, APOBEC3A
For WB starting dilution is: 1:1000
This gene is a member of the cytidine deaminase gene
family. It is one of seven related genes or pseudogenes found in a
cluster, thought to result from gene duplication, on chromosome 22.
Members of the cluster encode proteins that are structurally and
functionally related to the C to U RNA-editing cytidine deaminase
APOBEC1. The protein encoded by this gene lacks the zinc binding
activity of other family members. The protein plays a role in
immunity, by restricting transmission of foreign DNA such as
viruses. One mechanism of foreign DNA restriction is deamination of
foreign double-stranded DNA cytidines to uridines, which leads to
DNA degradation. However, other mechanisms are also thought to be
involved, as anti-viral effect is not dependent on deaminase
activity. One allele of this gene results from the deletion of
approximately 29.5 kb of sequence between this gene, APOBEC3A, and
the adjacent gene APOBEC3B. The breakpoints of the deletion are
within the two genes, so the deletion allele is predicted to have
the promoter and coding region of APOBEC3A, but the 3' UTR of
APOBEC3B.
- Thielen, B.K., et al. J. Biol. Chem. 285(36):27753-27766(2010)
- Berger, A., et al. J. Biol. Chem. 285(16):12248-12254(2010)
- Stenglein, M.D., et al. Nat. Struct. Mol. Biol. 17(2):222-229(2010)
- Abe, H., et al. Hepatol. Res. 39(12):1159-1168(2009)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This APOBEC3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-49 amino acids from the N-terminal region of human APOBEC3A.
100913187, 200315
DNA dC->dU-editing enzyme APOBEC-3A
APOBEC3A
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
23 kDa
P31941
12644206
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cell Cycle,Obesity,Signal Transduction
P31941
Optimal dilutions for each application to be determined by the researcher.