Antibody Isotype:
Rabbit Ig
Antibody Clonality:
Polyclonal
Applications:- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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Further Information
Membrane-bound transcription factor site-2 protease, Endopeptidase S2P, Sterol regulatory element-binding proteins intramembrane protease, SREBPs intramembrane protease, MBTPS2, S2P
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
This gene encodes a intramembrane zinc metalloprotease,
which is essential in development. This protease functions in the
signal protein activation involved in sterol control of
transcription and the ER stress response. Mutations in this gene
have been associated with ichthyosis follicularis with atrichia and
photophobia (IFAP syndrome); IFAP syndrome has been quantitatively
linked to a reduction in cholesterol homeostasis and ER stress
response.
- Ming, A., et al. Pediatr Dermatol 26(4):427-431(2009)
- Oeffner, F., et al. Am. J. Hum. Genet. 84(4):459-467(2009)
- Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)
- Shen, J., et al. J. Biol. Chem. 279(41):43046-43051(2004)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
This MBTPS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-44 amino acids from the N-terminal region of human MBTPS2.
51360
Membrane-bound transcription factor site-2 protease
MBTPS2
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
57 kDa
O43462
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cell Cycle,Obesity,Signal Transduction
O43462
Optimal dilutions for each application to be determined by the researcher.