ProSci

HRD1 Antibody

Product Code:
 
PSI-61-139
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis of HRD1 Antibody in SK-BR-3 cell line lysates (35ug/lane)
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Western blot analysis of HRD1 Antibody in SK-BR-3 cell line lysates (35ug/lane)

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PSI-61-139-400ul400ul£626.00
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Further Information

Additional Names:
E3 ubiquitin-protein ligase synoviolin, 632-, Synovial apoptosis inhibitor 1, SYVN1, HRD1, KIAA1810
Application Note:
For WB starting dilution is: 1:1000
Background:
HRD1 encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. This gene and the mitochondrial ribosomal protein L49 gene use in their respective 3' UTRs some of the same genomic sequence.
Background References:
  • Bernardi, K.M., et al. Mol. Biol. Cell 21(1):140-151(2010) Ballar, P., et al. Int. J. Biochem. Cell Biol. 42(1):167-173(2010) Shmueli, A., et al. Biochem. Biophys. Res. Commun. 390(3):758-762(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Xenopus
Immunogen:
This HRD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-138 amino acids from the N-terminal region of human HRD1.
NCBI Gene ID #:
84447
NCBI Official Name:
E3 ubiquitin-protein ligase synoviolin
NCBI Official Symbol:
SYVN1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
68 kDa
Protein Accession #:
Q86TM6
Protein GI Number:
134035039
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Cell Cycle,Signal Transduction
Swissprot #:
Q86TM6
User NOte:
Optimal dilutions for each application to be determined by the researcher.