ProSci

VRK1 Antibody

Product Code:
 
PSI-62-888
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western Blot at 1:2000 dilution Lane 1: Jurkat whole cell lysates Lane 2: 293T/17 whole cell lysates Lane 3: MCF-7 whole cell lysates Lysates/proteins at 20 ug per lane.
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Western Blot at 1:2000 dilution Lane 1: Jurkat whole cell lysates Lane 2: 293T/17 whole cell lysates Lane 3: MCF-7 whole cell lysates Lysates/proteins at 20 ug per lane.

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PSI-62-888-400ul400ul£626.00
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Further Information

Additional Names:
Serine/threonine-protein kinase VRK1, Vaccinia-related kinase 1, VRK1
Application Note:
For WB starting dilution is: 1:2000
Background:
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.
Background References:
  • Nezu, J., et al., Genomics 45(2):327-331 (1997).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This VRK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 366-396 amino acids from the Central region of human VRK1.
NCBI Gene ID #:
7443
NCBI Official Name:
Serine/threonine-protein kinase VRK1
NCBI Official Symbol:
VRK1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
45 kDa
Protein Accession #:
Q99986
Protein GI Number:
45593726
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle,Signal Transduction
Swissprot #:
Q99986
User NOte:
Optimal dilutions for each application to be determined by the researcher.