Further Information
O-phosphoseryl-tRNA(Sec) selenium transferase, Liver-pancreas antigen, LP, SLA-p35, SLA/LP autoantigen, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase, Sep-tRNA:Sec-tRNA synthase, SepSecS, Soluble liver antigen, SLA, UGA suppressor tRNA-associated protein, tRNA(Ser/Sec)-associated antigenic protein, SEPSECS, TRNP48
For WB starting dilution is: 1:1000
The 21st amino acid, selenocysteine (sec), is distinct
from other amino acids because it lacks its own tRNA synthetase and
is the only amino acid synthesized on its cognate tRNA. Synthesis
of sec begins with acylation of tRNA(sec) (TRSP; MIM 165060) by
seryl-tRNA synthetase (SARS; MIM 607529) to give ser-tRNA(sec),
which is subsequently phosphorylated by O-phosphoseryl-tRNA kinase
(PSTK; MIM 611310) to give O-phosphoseryl-tRNA(sec). SEPSECS
catalyzes the final step of sec synthesis by converting
O-phosphoseryl-tRNA(sec) to selenocysteinyl-tRNA(sec) using
selenophosphate as the selenium donor (Palioura et al., 2009
[PubMed 19608919]).
- Agamy, O., et al. Am. J. Hum. Genet. 87(4):538-544(2010)
- Hart, K., et al. Lung Cancer (2010) In press :
- Volkmann, M., et al. J. Autoimmun. 34(1):59-65(2010)
- Palioura, S., et al. Science 325(5938):321-325(2009)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This SEPSECS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 444-474 amino acids from the C-terminal region of human SEPSECS.
51091
O-phosphoseryl-tRNA(Sec) selenium transferase
SEPSECS
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
56 kDa
Q9HD40
62287911
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunology
Q9HD40
Optimal dilutions for each application to be determined by the researcher.