ProSci

SGSH Antibody

Product Code:
 
PSI-64-012
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western Blot at 1:4000 dilution + HepG2 whole cell lysate Lysates/proteins at 20 ug per lane.
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Western Blot at 1:4000 dilution + HepG2 whole cell lysate Lysates/proteins at 20 ug per lane.

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PSI-64-012-400ul400ul£626.00
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Further Information

Additional Names:
N-sulphoglucosamine sulphohydrolase, Sulfoglucosamine sulfamidase, Sulphamidase, SGSH, HSS
Application Note:
For WB starting dilution is: 1:4000
Background:
SGSH is one of several enzymes involved in the lysosomal degradation of heparan sulfate. Mutations in this gene are associated with Sanfilippo syndrome A, one type of the lysosomal storage disease mucopolysaccaridosis III, which results from impaired degradation of heparan sulfate. Transcripts of varying sizes have been reported but their biological validity has not been determined.
Background References:
  • Sleat, D.E., et al. Mol. Cell Proteomics 5(4):686-701(2006)
  • Bekri, S., et al. J. Inherit. Metab. Dis. 28(4):601-602(2005)
  • Muschol, N., et al. Hum. Mutat. 23(6):559-566(2004)
  • Zhang, H., et al. Nat. Biotechnol. 21(6):660-666(2003)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This SGSH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 420-449 amino acids from the C-terminal region of human SGSH.
NCBI Gene ID #:
6448
NCBI Official Name:
N-sulphoglucosamine sulphohydrolase
NCBI Official Symbol:
SGSH
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
57 kDa
Protein Accession #:
P51688
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Signal Transduction
Swissprot #:
P51688
User NOte:
Optimal dilutions for each application to be determined by the researcher.