ProSci

B4GALT6 Antibody

Product Code:
 
PSI-55-351
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Fluorescence-activated cell sorting (FACS)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
1 / 3
Western blot analysis in MDA-MB231 cell line lysates (35ug/lane).
2 / 3
B4GALT6 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
3 / 3
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Western blot analysis in MDA-MB231 cell line lysates (35ug/lane).
B4GALT6 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.

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PSI-55-351-400ul400ul£626.00
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Further Information

Additional Names:
Beta-1,4-galactosyltransferase 6, Beta-1,4-GalTase 6, Beta4Gal-T6, b4Gal-T6, 241-, UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6, Glucosylceramide beta-1,4-galactosyltransferase, Lactosylceramide synthase, LacCer synthase, UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase, B4GALT6
Application Note:
For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100

For FACS starting dilution is: 1:10~50
Background:
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene is a lactosylceramide synthase important for glycolipid biosynthesis.
Background References:
  • Landers, J.E., et al. Proc. Natl. Acad. Sci. U.S.A. 106(22):9004-9009(2009) Gevaert, K., et al. Nat. Biotechnol. 21(5):566-569(2003) Fan, Y., et al. DNA Seq. 13(1):1-8(2002) Amado, M., et al. Biochim. Biophys. Acta 1473(1):35-53(1999) Takizawa, M., et al. Biochim. Biophys. Acta 1438(2):301-304(1999)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This B4GALT6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 319-346 amino acids from the C-terminal region of human B4GALT6.
NCBI Gene ID #:
9331
NCBI Official Name:
Beta-1,4-galactosyltransferase 6
NCBI Official Symbol:
B4GALT6
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
45 kDa
Protein Accession #:
Q9UBX8
Protein GI Number:
13123991
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Obesity,Signal Transduction
Swissprot #:
Q9UBX8
User NOte:
Optimal dilutions for each application to be determined by the researcher.